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Dynamic Assembly of Cascade Enzymes by the Shape Transformation of a DNA Scaffold
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Lin, P.; Dinh, H.; Morita, Y.; Nakata, E.; Morii, T.
Adv. Funct. Mater. 2023, 2215023
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Controlled Assembly of Fluorophores inside a Nanoliposome
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Konishi, H.; Nakata, E.; Komatsubara, F.; Morii, T.
Molecules 2023, 28 (2), 911
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FRET-Based Cathepsin Probes for Simultaneous Detection of Cathepsin B and D Activities
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Zhang, Z.; Nakata, E.; Shibano, Y.; Morii, T.
ChemBioChem 2022, 23 (19), e202200319
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A two-step screening to optimize the signal response of an auto-fluorescent protein-based biosensor.
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Tajima, S.; Nakata, E.; Sakaguchi, R.; Saimura, M.; Mori, Y.; Morii, T.
RSC Adv. 2022, 24, 15407-15419
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Topologically-Interlocked Minicircles as Probes of DNA Topology and DNA-Protein Interactions.
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Rajendran, A.; Krishnamurthy, K.; Park, P.; Nakata, E.; Kwon, Y.; Morii, T.
Chem. Eur. J. 2022, 28, e202200108
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Mechanistic Aspects for The Modulation of Enzyme Reactions on the DNA Scaffold
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Lin, P.; Yang, H.; Nakata, E.; Morii, T.
Molecules 2022, 27, 6309
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The Methods to Assemble Functional Proteins on DNA Scaffold and their Applications
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Nakata, E.; Zhang, S.; Dinh, H.; Lin, P.; Morii, T.
DNA Origami: Structures, Technology, and Applications, 2022, pp. 261-280
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Stimuli-Responsible SNARF Derivatives as a Latent Ratiometric Fluorescent Probe
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Nakata, E.; Gerelbaatar, K.; Komatsubara, F.; Morii, T.
Molecules 2022, 27 (21), 7181
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Enzyme Function on DNA Nanostructure
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Nakata, E.; Morii, T.
kobunshi 2022, 71, 631-635
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Augmentation of an Engineered Bacterial Strain Potentially Improves the Cleanup of PCB Water Pollution
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Hara, T.; Takatsuka, Y.; Nakata, E. and Morii, T.
Microbiol. Spectr., 2021, 9, e01926-21
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Tuning the Reactivity of a Substrate for SNAP-Tag Expands Its Application for Recognition-Driven DNA-Protein Conjugation
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Zhang, Z.; Nakata, E.; Dinh, H.; Saimura, M.; Rajendran, A.; Matsuda, K. and Morii, T.
Chem. Eur. J., 2021, 27, 18118-18128
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Conditional dependence of enzyme cascade reaction efficiency on the inter-enzyme distance
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Lin, P.; Dinh, H.; Nakata, E. and Morii, T.
Chem. Commun., 2021,57, 11197-11200
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Dynamic Shape Transformation of a DNA Scaffold Applied for an Enzyme Nanocarrier
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Lin, P.; Dinh, H.; Nakata, E. and Morii, T.
Front. Chem., 2021, 9
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Stabilization and structural changes of 2D DNA origami by enzymatic ligation
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Rajendran, A.; Krishnamurthy, K.; Giridasappa, A.; Nakata, E.; Morii, T.
Nucleic Acids Res., 2021, 49, 7884-7900
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A facile combinatorial approach to construct a ratiometric fluorescent
sensor: application for the real-time sensing of cellular pH changes
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Nakata, E.; Hirose, H.; Gerelbaatar, K.; Arafiles, J. V. V.; Zhang, Z.;
Futaki, S.; Morii, T.
Chem. Sci., 2021, accepted
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Evaluation of the role of the DNA surface for enhancing the activity of scaffolded enzymes
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Lin, P.; Dinh, H.; Morita, Y.; Zhang Z.: Nakata, E.; Kinoshita, M.; Morii,
T.
Chem. Commun. 2021, 57, 3925-3928
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RNA-Peptide Conjugation through an Efficient Covalent Bond Formation
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Nakano, S.; Seko, T.; Zhang, Z.; Morii, T.
Appl. Sci. 2020, 10(24), 8920
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A Systematic Review of the Efficacy and Safety of Favipiravir (Avigan)
for the Treatment of Novel COVID-19 Infections
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Bag, S. S.; Shinha, S.; Saito, I.
Medical Research Archives 2020, 8(8)
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Cryogenic Far-Field Fluorescence Nanoscopy: Evaluation with DNA Origami
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Furubayashi, T.; Ishida, K.; Nakata, E.; Morii, T.; Naruse, K.; Matsushita, M.; Fujiyoshi, S.
J. Phys. Chem. B 2020, 124(35), 7525-7536
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Enhanced enzymatic activity exerted by a packed assembly of a single type of enzyme
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Dinh, H.; Nakata, E.; Mutsuda-Zapater, K.; Saimura, M.; Kinoshita, M.; Morii, T.
Chem. Sci. 2020, 11, 9088-9100
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Chapter Nine - Receptor-based fluorescent sensors constructed from ribonucleopeptide
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Nakano, S.; Konishi, H; Morii, T.
Methods Enzymol. 2020, 641, 183-223
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Fluorescence detection of the nitric oxide-induced structural change at the putative nitric oxide sensing segment of TRPC5
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Tajima, S.; Nakata, E.; Sakaguchi, R.; Saimura, M.; Mori, Y.; Morii, T.
Bioorg. Med. Chem. 2020, 28(8), 115430
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Influence of polymer molecular weight on the properties of in situ synthesized silver-methylcellulose nanocomposite films with a CO2 laser
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Nishikawa, H.; Nakata, E.; Nakano, S.; Nakajima, T.; Morii, T.
J. Mater. Sci. 2020, 55, 2090-2100
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Detection of Inositol Phosphates by Split PH Domains
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Sakaguchi, R.; Tajima, S.; Mori, Y.; Morii, T.
Inositol Phosphates 2019, 47-57 (Part of the Methods in Molecular Biology book series (MIMB, volume 2091))
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Reaction of ribulose biphosphate carboxylase/oxygenase assembled on a DNA scaffold
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Dinh, H; Nakata, E.; Lin, P.; Saimura, M.; Ashida, H.; Morii, T.
Bioorg. Med. Chem. 2019, 22, 115120
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Protein adaptors assemble functional proteins on DNA scaffolds
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Ngo, T.; Dinh, H.; Nguyen, T.M.; Liew, F-F.; Nakata, E.; Morii, T.
Chem. Commun. 2019, 55, 12428-12446
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Rational design of a DNA sequence-specific modular protein tag by tuning the alkylation kinetics
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Nguyen, T.M.; Nakata, E.; Zhang, Z.; Saimura, M.; Dinh, H.; Morii, T.
Chem. Sci. 2019, 10, 9315-9325
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Contribution of Coiled-Coil Assembly to Ca(2+)/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes
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Polat, O.K.; Uno, M.; Maruyama, T.; Tran, H.N.; Imamura, K.; Wong, C.F.; Sakaguchi, R.; Ariyoshi, M.; Itsuki, K.; Ichikawa, J.; Morii, T.; Shirakawa, M.; Inoue, R.; Asanuma, K.; Reiser, J.; Tochio, H.; Mori, Y.; Mori, M.X.
J. Am. Soc. Nephrol. 2019, 30(9), 1587-1603.
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Nanometer Accuracy in Cryogenic Far-Field Localization Microscopy of Individual Molecules
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Furubayashi, T.; Ishida, K.; Kashida, H.; Nakata, E.; Morii, T.; Matsushita, M.; Fujiyoshi, S.
J. Phys. Chem. Lett. 2019, 10, 5841-5846.
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DNA binding adaptors to assemble proteins of interest on DNA scaffold
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Nakata, E.; Dinh, H.; Nguyen, T.M.; Morii, T.
Methods Enzymol. 2019, 617, 287-322.
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Highly selective dual sensing of ATP and ADP using fluorescent ribonucleopeptide sensors
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Nakano, S.; Shimizu, M.; Dinh, H.; Morii, T.
Chem. Commun. 2019, 55(11), 1611-1614.
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Covalent Bond Formation by Modular Adaptors to Locate Multiple Enzymes on a DNA Scaffold
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Nakata, E.; Nakano, S.; Rajendran, A.; Morii, T.
Kinetic Control in Synthesis and Self-Assembly 2019, pp.163-183. (ISBN
978-0-12-812126-9)
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DNA Origami Scaffolds as Templates for Functional Tetrameric Kir3 K+ Channels
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Kurokawa, T.; Kiyonaka, S.; Nakata, E.; Endo, M.; Koyama, S.; Mori, E.; Tran, N.H.; Dinh, H.; Suzuki, Y.; Hidaka, K.; Kawata, M.; Sato, C.; Sugiyama, H.; Morii*, T.; Mori*, Y.
Angew. Chem. Int. Ed. 2018, 57(10), 2586-2591.
→More Detail →IAE-HP |
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効率的な多段階酵素反応を実現する分子コンビナート
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中田栄司・森井 孝
バイオサイエンスとインダストリー vol.76 No.1 (2018)
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想いをつなぐ−生物の機能を化学で理解する
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森井 孝
化学と工業 vol.71 No.2 (2018)
※コラム「私の自慢」
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A diversity-oriented library of fluorophore-modified receptors constructed
from a chemical library of synthetic fluorophores
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Nakano, S.; Tamura, T.; Das, R. K.; Nakata, E.; Chang, Y.-T.; Morii, T.
ChemBioChem 2017, 18, 2212-2216.
→More Detail DOI: 10.1002/cbic.201700403 |
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Design of Modular Protein-Tags for the Orthogonal Covalent Bond Formation
at Specific DNA Sequences
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Nguyen, T. M.; Nakata, E.; Saimura, M.; Dinh, H.; Morii, T.
J. Am. Chem. Soc. 2017, 139, 8487-8496.
→More Detail DOI: 10.1021/jacs.7b01640
日本語版プレスリリース →IAE-HP →PDF
|
※ 本論文の寄稿記事がAcademist Journalに掲載されました。
酵素を“1分子ずつ”狙った場所に配置する
-多段階反応を効率的に進行させる分子コンビナートをつくる
中田 栄司・森井 孝
2017年7月14日付研究コラム |
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Construction of a library of structurally diverse ribonucleopeptides with
catalytic groups.
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Tamura, T.; Nakano, S.; Nakata, E.; Morii, T.
Bioorg. Med. Chem. 2017, 25, 1881-1888.
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(review) A Bioorganic Chemistry Approach to Understanding Molecular Recognition in Protein-Nucleic Acid Complexes
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Morii, T.
Bull. Chem. Soc. Jpn. 2017, 90, 1309-1317.
→More Detail DOI: 10.1246/bcsj.20170273 |
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(review) Nucleic acids-templated enzyme cascades
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Rajendran, A.; Nakata, E.; Nakano, S.; Morii, T.
ChemBioChem 2017, 18, 696-716.
→More Detail
This review was selected as "ChemBioChem Readers‘ Choice 2019" |
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DNA折り紙
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森井 孝
高分子 2017, 66, 107.
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若手研究者からのメッセージ
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中田栄司
バイオテクノロジー部会 NEWS LETTER 2017, 20, 7.
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ナノレベル間隔で異なる酵素を並べる！
─複雑な多段階反応を可能にする分子コンビナートへの挑戦─
|
中田栄司・森井 孝
月刊 化学 2017年11月号
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巻頭言「創造の動機」
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森井 孝
生体関連部会 NEWS LETTER vol.32, No.1, (2017.6.19)
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Spatially Organized Enzymes Drive Cofactor-Coupled Cascade Reactions.
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Ngo, T. A.; Nakata, E.; Saimura, M.; Morii, T.
J. Am. Chem. Soc. 2016, 138, 3012-3021.
※This paper was introduced as "Virtual Issue on Engineered Biomolecular
Catalysts" on ACS web site (→Link)
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Latent pH-responsive ratiometric fluorescent cluster based on self-assembled
photoactivated SNARF derivatives.
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Nakata, E.; Yukimachi, Y.; Uto, Y.; Hori, H.; Morii T.
Sci. Tech. Adv. Mater. 2016, 17, 431-436.
→More Detail (Open access) |
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自己集合を利用した蛍光プローブのユニークな活用法
−洗浄操作を必要としない細胞内レシオイメージングへの応用−
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中田栄司
バイオマテリアル 2016, 34, 198-203.
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DNAナノ構造体に酵素を配置した分子スイッチボード
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中田栄司
生体機能関連化学部会 NEWS LETTER 2016, Vol.31, No.3.
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Validating subcellular thermal changes revealed by fluorescent thermosensors.
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Kiyonaka, S.; Sakaguchi, R.; Hamachi, I.; Morii, T.; Yoshizaki, T.; Mori, Y.
Nature Methods 2015, 12, 801-802.
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A modular zinc finger adaptor accelerates the covalent linkage of proteins at specific locations on DNA nanoscaffolds.
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Nakata, E.; Dinh, H.; Ngo, T. A. ; Saimura, M.; Morii, T.
Chem. Commun. 2015, 51, 1016-1019.
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Self-Assembled Fluorescent Nanoprobe for the Detection of Fluoride Ions
in Aqueous Solutions.
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Nakata, E.; Nazumi, Y.; Yukimachi, Y.; Uto, Y.; Hori, H.; Morii, T.
Bull. Chem. Soc. Jpn., 2015, 88, 327-329.
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Phosphorylation regulates fibrillation of an aggregation core peptide in
the second repeat of microtubule-binding domain of human tau.
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Inoue, M.; Kaida, S.; Nakano, S.; Annoni, C.; Nakata, E.; Konno, T.; Morii, T.
Bioorg. Med. Chem. 2014, 22, 6471-6480.
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Peptidosteroid Tweezers Revisited: DNA Binding Through an Optimised Design.
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Carrette, L. L.; Morii, T.; Madder, A.
Eur. J. Org. Chem. 2014, 2883-2891.
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A protein adaptor to locate a functional protein dimer on molecular switchboard.
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Ngo, T. A.; Nakata, E.; Saimura, M.; Kodaki, T.; Morii, T.
Methods 2014, 67, 142-150.
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A novel strategy to design latent ratiometric fluorescent pH probes based
on self-assembled SNARF derivatives.
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Nakata, E.; Yukimachi, Y.; Nazumi, Y.; Uwate, M.; Maseda, H.; Uto, Y.; Hashimoto,T.; Okamoto, Y.; Hori, H.; Morii, T.
RSC Advances 2014, 4, 348-357.
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細胞内レシオ型蛍光pHプローブ開発のための自己集合化ナノプローブの合理的設計戦略
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中田栄司
和光純薬時報 2014, 82, 6-8
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SNARF誘導体の自己集合化戦略に基づいた外部刺激応答性のレシオ型蛍光pHプローブの開発
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中田栄司
ナノ学会会報 2014, 12, 51-56
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Toxicity inspired cross-linking for probing DNA-peptide interactions.
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Carrette, L. L.; Morii, T.; Madder, A.
Bioconjug. Chem. 2013, 24, 2008-2014.
→More Detail |
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Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells.
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Kiyonaka, S.; Kajimoto, T.; Sakaguchi, R.; Shinmi, D.; Omatsu-Kanbe, M.;
Matsuura, H.; Imamura, H.; Yoshizaki, T.; Hamachi, I.; Morii, T.; Mori,
Y.
Nat. Methods 2013, 10, 1232-1238.
→More Detail |
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Simultaneous Detection of ATP and GTP by Covalently Linked Fluorescent Ribonucleopeptide Sensors.
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Nakano, S.; Fukuda, M.; Tamura, T.; Sakaguchi, R.; Nakata, E.; Morii, T.
J. Am. Chem. Soc. 2013, 135, 3465-3473.
→More Detail |
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A Peptide Nucleic Acid (PNA) Heteroduplex Probe Containing an Inosine-Cytosine Base Pair Discriminates a Single-Nucleotide Difference in RNA.
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Matsumoto, K.; Nakata, E.; Tamura, T.; Saito, I.; Aizawa, Y.; Morii, T.
Chem. Eur. J. 2013, 19, 5034-5040.
→More Detail |
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Arranging enzymes and receptors with nanometer-scale precision on molecular
switchboards.
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Ngo T. A.; Nakata, E.; Morii, T.
J. Biomol. Struct. Dyn. 2013, 31, 86
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Construction of ratiometric fluorescent sensors by ribonucleopeptides.
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Annoni, C.; Nakata, E.; Tamura, T.; Liew, F. F.; Nakano, S.; Gelmi, M. L.; Morii, T.
Org. Biomol. Chem. 2012, 10, 8767-8769.
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Zinc finger proteins for site-specific protein positioning on DNA origami.
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Nakata, E.; Liew, F. F.; Uwatoko, C.; Kiyonaka, S.; Mori, Y.; Katsuda,
Y.; Endo, M.; Sugiyama, H.; Morii T.
Angew Chem. Int. Ed. 2012, 51, 2421-2424.
→More Detail |
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Positional effects of phosphorylation on the stability and the morphology of tau-related amyloid fibrils.
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Inoue, M.; Konno, T.; Tainaka, K.; Nakata, E.; Yoshida, H.; Morii, T.
Biochemistry 2012, 51, 1396-1406.
→More Detail |
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Study on the Application of Furan Crosslinking at the Protein-DNA Interface.
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Carrette, L. L. G.; Gattner, M.; Van den Begin, J.; Carell, T.; Morii,
T.; Madder, A.
J. Pep. Sci. 2012, 18, S99.
→More Detail |
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タンパク質ベースの蛍光バイオセンサー
ここまで進んだバイオセンシング・イメージング（分担執筆）
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中田 栄司, 森井 孝
日本化学会 編著, 東京, 2012年11月
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Design and synthesis of biotinylated inositol 1,3,4,5-tetrakisphosphate targeting Grp1 pleckstrin homology domain.
|
Anraku, K.; Inoue, T.; Sugimoto, K.; Kudo, K.; Okamoto, Y.; Morii, T.; Mori, Y.; Otsuka, M.
Bioorg. Med. Chem. 2011, 19, 6833-6841.
→More Detail |
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A ribonucleopeptide module for effective conversion of an RNA aptamer to a fluorescent sensor.
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Liew, F. F.; Hayashi, H.; Nakano, S.; Nakata, E.; Morii, T.
Bioorg. Med. Chem. 2011, 19, 5771-5775.
→More Detail |
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Construction of dopamine sensors by using fluorescent ribonucleopeptide
complexes.
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Liew, F. F.; Hasegawa, T.; Fukuda, M.; Nakata, E.; Morii, T.
Bioorg. Med. Chem. 2011, 19, 4473-4481.
→More Detail |
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Facile conversion of RNA Aptamers to modular fluorescent sensors with tunable
detection wavelengths.
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Nakano, S.; Nakata, E.; Morii, T.
Bioorg. Med. Chem. Lett. 2011, 21, 4503-4506.
→More Detail |
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Structural Aspects for the Recognition of ATP by Ribonucleopeptide Receptors.
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Nakano, S.; Mashima, T.; Matsugami, A.; Inoue, M.; Katahira, M.; Morii,
T.
J. Am. Chem. Soc. 2011, 133, 4567-4579.
→More Detail |
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Design and synthesis of highly solvatochromic fluorescent 2'-deoxyguanosine
and 2'-deoxyadenosine analogs.
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Matsumoto, K.;Takahashi, N.; Suzuki, A.; Morii, T.; Saito, Y.; Saito, I.
Bioorg. Med. Chem. Lett. 2011, 21, 1275-1278.
→詳細を表示 |
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Selective assembly of photosynthetic antenna proteins into a domain-structured
lipid bilayer for the construction of artificial photosynthetic antenna
systems: structural analysis of the assembly using surface plasmon resonance
and atomic force microscopy.
|
Sumino, A.; Dewa, T.; Kondo, M.; Morii, T.; Hashimoto, H.; Gardiner, AT.;
Cogdell, RJ.; Nango, M.
Langmuir 2011, 27, 1092-1099.
→詳細を表示 |
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The mechanism of fibril formation of a non-inhibitory serpin ovalbumin
revealed by the identification of amyloidogenic core regions.
|
Tanaka, N.; Morimoto, Y.; Noguchi, Y.; Tada, T.; Waku, T.; Kunugi, S.;
Morii, T.; Lee, YF.; Konno, T; Takahashi, N.
J. Biol. Chem. 2011, ,286, 5584-5594.
→More Detail |
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Recent progress in the construction methodology of fluorescent biosensors based on biomolecules.
|
Nakata, E.; Liew, F.F.; Nakano, S.; Morii, T.
"Biosensors Emerging Materials and Applications, Chapter 7",
DOI: 10.5772/17724
→More Detail |
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Design of environmentally sensitive fluorescent 2'-deoxyguanosine containing arylethynyl moieties: Distinction of thymine base by base-discriminating fluorescent (BDF) probe.
|
Shinohara, Y.; Matsumoto, K.; Kugenuma, K,; Morii, T.; Saito, Y.; Saito, I.
Bioorg. Med. Chem. Lett. 2010, 20, 2817-2820.
→詳細を表示 |
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An in vitro fluorescent sensor reveals intracellular Ins(1,3,4,5)P4 dynamics
in single cells.
|
Sakaguchi, R.; Tainaka, K.; Shimada, N.; Nakano, S.; Inoue, M.; Kiyonaka,
S.; Mori, Y.; Morii, T.
Angew. Chem. Int. Ed. 2010, 49, 2150-2153.
→More Detail |
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Design Strategies of Fluorescent Biosensors Based on Biological macromolecular
Receptors.
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Tainaka, K.; Sakaguchi, R.; Hayashi, H.; Nakano, S.; Liew, F.-F.; Morii,
T.
Sensors 2010, 10, 1355-1376.
→More Detail |
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Selective and direct inhibition of TRPC3 channels underlies biological
activities of a pyrazole compound.
|
Kiyonaka, S.; Kato, K.; Nishida, M.; Mio, K.; Numaga, T.; Sawaguchi, Y.;
Yoshida, T.; Wakamori, M.; Mori, E.; Numata, T.; Ishii, M.; Takemoto, H.;
Ojida, A.; Watanabe, K.; Uemura, A.; Kurose, H.; Morii, T. Kobayashi, T.;
Sato, Y.; Sato, C.; Hamachi, I.; Mori, Y.
Proc. Natl. Acad. Sci. U S A 2009, 106, 5400-5405.
→More Detail |
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The amyloid fibrillization of phosphorylated human tau core peptides.
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Inoue, M.; Tainaka, K.; Hirata, A.; Konno, T.; Morii, T.
Trans. Mat. Res. Soc. Jpn. 2009, 34, 517-520.
→More Detail |
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Development of A Fluorescent Ribonucleopeptide Sensor for Histamine.
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Fukuda, M.; Hayashi, H.; Hasegawa, T.; Morii, T.
Trans. Mat. Res. Soc. Jpn. 2009, 34, 515-527.
→More Detail |
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A single circularly permuted GFP sensor for inositol-1,3,4,5-tetrakisphosphate
based on a split PH domain.
|
Sakaguchi, R.; Endoh, T.; Yamamoto, S.; Tainaka, K.; Sugimoto, K.; Fujieda,
N.; Kiyonaka, S.; Mori, Y.; Morii, T.
Bioorg. Med. Chem. 2009, 17, 7381-7386.
→More Detail |
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Design of extremely facile 3'- and 5'-ends free molecular beacons using
C8 alkylamino substituted 2'-deoxyguanosine.
|
Matsumoto, K.; Shinohara, Y.; Numajiri, K.; Ishioroshi, S.; Morii, T.; Saito, Y.; Saito, I.
Nucleic Acids Symp. Ser. 2009, 53, 141-142.
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Covalently linked fluorescent ribonucleopeptide sensors.
|
Fukuda, M.; Liew, F-F.; Morii, T.
Nucleic Acids Symp. Ser. 2009, 53, 257-258.
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Structural aspects for the function of ATP-binding ribonucleopeptide receptors.
|
Fukuda, M., Fong-Fong, L., Morii, T.
Nucleic Acids Symp. Ser. 2009, 53, 257-258.
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Structural analysis of ribonucleopeptide aptamer against ATP.
|
Mashima, T.; Matsugami, A.; Nakano, S.; Inoue, M.; Fukuda, M.; Morii, T.; Katahira, M.
Nucleic Acids Symp. Ser. 2009, 53, 267-268.
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A Modular Strategy for Development of RNA-Based Fluorescent Sensors.
|
Fukuda, M.; Hasegawa, T.; Hayashi, H.; Morii, T.
"Combinatorial methods for chemical and biological sensors." Chapter 10, pp. 249-269, R. A. Potyrailo and V. M. Mirsky (Eds.), Springer, 2009.
→More Detail |
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Design and synthesis of biotinylated inositol phosphates relevant to the
biotin-avidin techniques.
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Anraku, K.; Inoue, T.; Sugimoto, K.; Morii, T.; Mori, Y.; Okamoto, Y.;
Otsuka, M.
Org. Biomol. Chem. 2008, 6, 1822-1830.
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Context-dependent fluorescence detection of a phosphorylated tyrosine residue
by a ribonucleopeptide.
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Hasegawa, T.; Hagiwara, M.; Fukuda, M.; Nakano, S.; Fujieda, N.; Morii, T.
J. Am. Chem. Soc. 2008, 130, 8804-8812.
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Charge-pairing mechanism of phosphorylation effect upon amyloid fibrillation
of human tau core peptide.
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Inoue, M.; Hirata, A.; Tainaka, K.; Morii, T.; Konno, T.
Biochemistry. 2008, 47, 11847-11857.
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Construction of a stable functional ribonucleopeptide complex by the covalent linking method.
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Fukuda, M.; Nakano, S.; Tainaka, K.; Fujieda, N.; Morii T.
Nucleic Acids Symp. Ser (Oxf). 2008, 52, 195-196.
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Selective recognition of a tetra-amino-acid motif containing phosphorylated
tyrosine residue by ribonucleopeptide.
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Nakano, S.; Hasegawa, T.; Fukuda, M.; Fujieda, N.; Tainaka, K.; Morii, T.
Nucleic Acids Symp. Ser. (Oxf). 2008, 52, 199-200.
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Development of ribonucleopeptide-based fluorescent sensors for biologically
active amines based on the stepwise molding strategy.
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Tainaka, K.; Hasegawa, T.; Fukuda, M.; Nakano, S.; Fujieda, N.; Morii, T.
Nucleic Acids Symp. Ser. (Oxf). 2008, 52, 201-202.
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細胞内シグナル伝達物質リアルタイム検出用プローブ
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森井 孝
「バイオインダストリー」、Vol. 25 (2), 7-14, (2008).
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RNA-タンパク質複合体の分子進化を利用したアプタマーとセンサーの開発
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福田将虎、森井 孝
生物物理、Vol. 48, 239-242 (2008).
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Synergic action of polyanionic and non-polar cofactors in fibrillation
of human islet amyloid polypeptide.
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Konno, T.; Oiki S.; Morii T.
FEBS Lett. 581, 1635-1638 (2007).
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Amyloid-forming propensity of the hydrophobic non-natural amino acid on
the fibril-forming core peptide of human tau.
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Hirata, A.; Sugimoto, K.; Konno, T.; Morii, T.
Bioorg. Med. Chem. Lett. 17, 2971-2974 (2007).
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Stepwise functionalization of ribonucleopeptides: optimization of the response
of fluorescen ribonucleopeptide sensors for ATP.
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Hasegawa, T.; Hagihara, M.; Fukuda, M.; Morii; T.
Nucleosides Nucleotides & Nucleic Acids 2007, 26, 1277-1281.
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Structure-based design of fluorescent biosensors from ribonucleopeptide
complexes.
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Hayashi, H.; Inoue, M.; Morii, T.
Nucleic Acids Symp. Ser. 2007, 51, 95-96.
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Controlling a substrate-binding geometry of ribonucleopeptide receptor.
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Fukuda, M.; Nakano, S.; Morii T.
Nucleic Acids Symp. Ser. 2007, 51, 421-422.
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Construction of ribonucleopeptide-based fluorescent sensors for biologically active amines.
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Hasegawa, T.; Hayashi, H.; Morii, T.
Nucleic Acids Symp. Ser. 2007, 51, 423-424.
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Design of Ribonucleopeptide-based Receptors and Fluorescent Sensors.
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Morii, T.
J. Biomol. Struct. Dynam. 2007, 24, 689.
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RNA-ペプチド複合体をもとにした機能性分子の創製
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森井 孝
「ゲノム化学：医学、分子生物学への応用と展開」化学フロンティア18, pp. 45-52,（2007）
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テーラーメイド蛍光センサーの開発
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森井 孝
「化学工業、Vol. 58 (5), 38-43, (2007).
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Nitric oxide activates TRP channels by cysteine S-nitrosylation.
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Yoshida, T.; Inoue, R.; Morii, T.; Takahashi, N.; Yamamoto, S.; Hara, Y.;
Tominaga, M.; Shimizu, S.; Sato, Y.; Mori, Y.
Nature Chem. Biol. 2006, 2, 596-607.
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A modular strategy for tailoring fluorescent biosensors from ribonucleopeptide complexes.
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Hagihara, M.; Fukuda, M.; Hasegawa, T.; Morii T.
J. Am. Chem. Soc. 2006, 128, 12932-12940.
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ケミカルバイオロジーのツールとしての機能性ミニチュアタンパク質
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森井 孝
化学工業、Vol. 57 (9), 8(656)-12(660), (2006).
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「ファージディスプレイ法を用いたセレクション （標的分子に結合する生体分子の作製）」
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福田将虎、杉本健二、森井 孝
生命科学研究レター, 22, 24-29 (2006)
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Stepwise Molding of a Highly Selective Ribonucleopeptide Receptor.
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Sato, S.; Fukuda, M.; Hagihara, M.; Tanabe, Y.; Ohkubo, K.; Morii, T.
J. Am. Chem. Soc. 2005, 127, 30-31.
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A Ribonucleopeptide Receptor Targets Phosphotyrosine.
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Hasegawa, T.; Ohkubo, M. K.; Yoshikawa, S.; Morii, T.
J. Surf. Sci. Nanotech. 2005, 3, 41-45.
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Covalent blocking of amyloid formation and protein aggregation by transglutaminase-catalyzed
intra-molecular cross-linking.
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Konno, T.; Morii, T.; Hirata, A.; Sato, S.; Naiki, H.; Oiki, S.; Ikura K.
Biochemistry 2005, 44, 2072-2079.
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Dual DNA recognition codes of a short peptide derived from the basic leucine
zipper protein EmBP1.
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Hirata, A.; Ueno, M.; Aizawa, Y.; Ohkubo, K.; Morii, T.; Yoshikawa, S.
Bioorg. Med. Chem.2005, 13, 3107-3116.
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Paradoxical inhibition of protein aggregation and precipitation by transglutaminase-catalyzed
intermolecular cross-linking.
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Konno, T.; Morii, T.; Shimidzu, H.; Oiki, S.; Ikura, K.
J. Biol. Chem. 2005, 280, 17520-17525.
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Ribonucleopeptides recognize the phosphotyrosine residue.
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Hasegawa, T.; Yoshikawa, S.; Morii T.
Nucleic Acids Res. Symp. Ser. 2005, 49, 79-80.
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Stepwise functionalization of ribonucleopeptide complexes to receptors
and sensors.
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Fukuda, M.; Tanabe, Y.; Morii, T.
Nucleic Acids Res. Symp. Ser. 2005, 49, 355-356.
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敬虔な生体高分子ファン？ それとも・・・
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森井 孝
RNA Network Newsletter, volume 3, number 2, 59-62, January 2005.
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Ribonucleopeptides: functional RNA-peptide complexes.
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Hagihara, M.; Hasegawa, T.; Sato, S.; Yoshikawa, S.; Ohkubo, K.; Morii, T.
Pep. Sci. 2004, 76, 66-68.
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Novel real time sensors to quantitatively assess in vivo inositol 1,4,5-trisphosphate
production in intact cells.
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Sugimoto, K.; Nishida, M.; Otsuka, M.; Makino, K.; Ohkubo, K.; Mori, Y.; Morii, T.
Cell. Chem. Biol. 2004, 11, 475-485.
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Design of sensing ribonucleopeptides for small ligands.
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Hagihara, M.; Hasegawa, T.; Tanabe, Y.; Sato, S.; Yoshikawa, S.; Ohkubo, K.; Morii, T.
Nucleic Acids Res. Symp. Ser. 2004, 48, 33-34.
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Recent advances in biosensing second messengers.
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Sugimoto, K.; Sakaguchi, R.; Mori, Y.; Morii, T.
Recent Res. Devel. Chem. 2004, 2, 73-89.
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タンパク質・核酸をもとにした機能性分子設計
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森井 孝
生命化学研究レター No.16, 10-18, 2004年10月
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Ribonucleopeptide receptors.
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Hagihara, M.; Hasegawa, T.; Sato, S.; Yoshikawa, S.; Ohkubo, K.; Morii, T.
Peptide Revolution: Genomics, Proteomics & Therapeutics. The Proceedings
Of The 18Th American Peptide Symposium M. Chorev, p. 556-558, T. K. Sawyer,
Ed., American Peptide Society (2004).
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Functional Reassembly of a Split PH Domain.
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Sugimoto, K.; Mori, Y.; Makino, K.; Ohkubo, K.; Morii, T.
J. Am. Chem. Soc. 2003, 125, 5000-5004.
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Regulatory interaction of sodium channel IQ-motif with calmodulin C-terminal
lobe.
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Mori, M.; Konno, T.; Morii, T.; Nagayama, K.; Imoto, K.
Biochem. Biophys. Res. Commun. 2003, 307, 290-296.
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Amplification of receptor signalling by Ca2+ entry-mediated translocation
and activation of PLCg2 in B lymphocytes.
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Nishida, N.; Sugimoto, K.; Hara, Y.; Mori, E.; Morii, T.; Kurosaki, T.; Mori, Y.
EMBO J. 2003, 22, 4677-4688.
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Design of a ribonucleopeptide biosensor.
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Hagihara, M.; Hirata, A.; Ohkubo, K.; Morii, T.
Nucleic Acids Res. Suppl. 2003, 3, 193-194.
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Optimization of an ATP-binding ribonucleopeptide receptor.
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Sato, S.; Hasegawa, T.; Hagihara, M.; Fukuda, M.; Ohkubo, K.; Morii, T.
Nucleic Acids Res. Suppl. 2003, 3, 239-240.
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Ribonucleopeptide receptors.
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Morii, T.; Ohkubo K.; Yoshikawa S.
Biopolymers 2003, 71(3), 323.
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Formation of a Fairly Stable Diazoate Intermediate of 5-Methyl-2'-deoxycytidine
by HNO2 and NO, and Its Implication to a Novel Mutation Mechanism in CpG
Site.
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Suzuki, T.; Yamada, M.; Nakamura, T.; Ide, H.; Kanaori, K.; Tajima, K.;
Morii,T.; Makino, K.
Bioorg. Med. Chem. 2002, 10, 1063-1067.
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A General Strategy to Determine a Target DNA Sequence of Short Peptide:
Application to a D-Peptide.
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Morii, T.; Tanaka, T.; Sato, S.; Hagihara, M.; Aizawa, Y.; Makino, K.
J. Am. Chem. Soc. 2002, 124, 180-181.
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A New Fluorescent Biosensor for Inositol Trisphosphate.
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Morii, T.; Sugimoto, K.; Makino, K.; Otsuka, M.; Imoto, K.; Mori, Y.
J. Am. Chem. Soc. 2002, 124, 1139-1140.
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Structure-Based Design of a Leucine Zipper Protein with New DNA Contacting
Region.
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Morii, T.; Sato, S.; Hagihara, M.; Mori, Y.; Imoto, K.; Makino, K.
Biochemistry 2002, 41, 2177-2183.
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In Vitro Selection of ATP-binding Receptors Using a Ribonucleopeptide Complex.
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Morii, T.; Hagihara, M.; Sato, S.; Makino, K.
J. Am. Chem. Soc. 2002, 124, 4617-4622.
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Chemical Approach to Untangle the Sequence-Specific DNA Binding by Proteins.
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Sato, S.; Hagihara, M.; Sugimoto, K.; Morii, T.
Chem-Eur. J. 2002, 22, 5067-5071.
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A new strategy to determine the target DNA sequence of a short peptide.
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Sato, S.; Honjyo, H.; Tsuji, S.; Hagihara, M.; Makino K.; Morii, T.
Nucleic Acids Res. Suppl. 2002, 2, 205-206.
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Sequence-specific DNA binding by short peptides.
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Morii T.; Makino, K.
Advances in DNA Sequence Specific Agents, 2002, 4, 105-137.
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