Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST)
Research area: Elucidation of biological mechanism of extracellular fine particles and the control system
Research project: Intracellular fate of extracellular fine particles and the control system
Sub-theme: Multiple sensing system of the intracellular environment
Sub-theme Leader：Prof. Takashi Morii
Project Period：FY2018 ‒ FY2023
Macropinocytosis is a central pathway to the cellular uptake of extracellular fine particles. In this research project, we develop novel sensing systems of the intracellular environment to elucidate the mechanism of cellular uptake and the intracellular fate of extracellular fine particles. The sensing system constructed by using DNA nanostructures would allow simultaneous and real-time monitoring of multiple environmental factors during the macropinocytosis.