Biofunctional Chemistry

Advanced Energy Utilization Division Biofunctional Chemistry Research Section

Associate Professor : Eiji NAKATA
Assistant Professor : LIN Peng
Professor (Concurrent): Toshiyuki NOHIRA

Our research group is exploring the design and the construction of biomacromolecules "tailored" for pursuing highly efficient energy utilization.

A design principle of functional biomolecules for highly effective energy utilization

A transition to renewable energy technologies requires new chemistry to learn from nature. It is our challenge to understand the efficient bioenergetic processes of nature and to construct human-engineered energy utilization systems. The research interests in our group focus on the design and assembly of biomacromolecules for energy conversion, catalysis and signal transduction in water, the solvent of life.
We take synthetic, organic chemical, biochemical and biophysical approaches to understand the biological molecular recognition and chemical reactions. Miniature proteins and protein/ nucleic acids assemblies are explored to construct artificial biomimetic devices mimicking the function of biological systems and imaging cellular signals by fluorescent biosensors. New biomolecular assemblies are designed to realize artificial receptors and enzymes based on the complex of RNA and protein, and artificial metabolic systems for useful chemicals.


Exploring functional biomacromolecules by using RNP complexes

Design strategies to tailor receptors, sensors and enzymes are explored by utilizing structurally well-defined protein-RNA complexes. Stepwise strategies of the structure-based design, in vitro selection and the chemical modification afford highly specific receptors for biologically important ligands, such as ATP and the phosphorylated tyrosine residue within a defined amino acid sequence.


Exploring functional biomacromolecules by using RNP complexes

Structure-based design provide alternative strategy to construct protein-based biosensors that assess intracellular dynamics of second messengers and metabolites.


  • 京都大学研究連携基盤
  • 国立大学附置研究所・センター長会議
  • 京都大学宇治キャンパス
  • 京大宇治地区三研究所技術部
  • 刊行物
  • 所内限定ページ
  • 京都大学